Kratom is used traditionally and in modern times for a wide range of applications. People most commonly use kratom as a stimulant, productivity enhancer, and to ease joint and mobility discomfort. 

While data on kratom is still rapidly emerging, most of its effects appear to stem from its effect on the opioid receptors on the body. Note this does not mean kratom itself is an opioid – merely that it binds to those receptors in the body to have a resulting effect. Kratom also binds to dopamine, serotonin, and alpha-2 receptors in the body – though the implications of this are unknown as of now. 

Kratom has become especially controversial in recent years. Because of its effects on the opioid receptor, the FDA and DEA have subsequently motioned to schedule kratom as a controlled substance. Fortunately for the millions of people who use kratom, these motions were reversed or dismissed due to public outcry. The truth is this. As with any consumable product, kratom has its risks. It wouldn’t be misleading to suggest, even, that kratom has more risks than most herbal products. There is a potential for dependence when taken in frequent, high doses for sustained periods (> 1 month), there are very noticeable side effects when too high of a dose is taken, and there is a potential for abuse – as with any psychoactive substance. It is believed by kratom advocates and users that the benefits and relief brought by kratom use far outweigh its risks, however. This stance is beginning to be shared by medical professionals and the general public as well. While there is certainly some degree of regulation and quality control needed for kratom products, the evidence and outpour of public opinion has started to build a case for kratom sticking around for the long term.

Kratom like anything else isn’t without the potential of side effects. The good news is that all of them appear to only occur in rare cases, high doses, or frequent use over a long period of time. Here are the most documented side effects to be cognizant of:

• Dependence: Cravings, dependence, and withdrawals – in the same vein as nicotine, caffeine, alcohol, or other recreational substances, use kratom in strict moderation and this won’t be a problem. If frequent use is warranted – incorporate “tolerance breaks” to give your body a break and prevent tolerance and dependence.
• Nervous system: Includes sweating, dry mouth, sedation, and rapid heart beat. These side effects tend to appear when too high a dose is used. For most people this translates to doses exceeding 8g of raw leaf product. 
• Liver enzyme elevation: This seems to occur from high doses and frequent usage over long periods of time. It’s been noted that liver enzyme levels return to normal after kratom use is stopped. 

Be wary of mixing kratom with any of the following types of medications:

• Sedatives – Includes any medications or other products that can make you drowsy. Kratom can produce drowsiness when taken in high doses, and this effect compounds with other substances leading to a higher degree of risk to the user.
• Benzodiazepines – Kratom can compound the drowsiness and dissociative effects of benzodiazepines such as alprazolam, diazepam, and clonazepam. Avoid using kratom if you are taking these types of medications.
• Opioids – As kratom exerts its effects through the opioid receptors, this can cause alot of problems if taken alongside opioid medications. This can manifest in a diminished or potentiated opioid effect, more opioid-like side effects, and even respiratory depression and death if taken in high doses. It is highly suggested to avoid using kratom with opioids entirely. 
• Naloxone – This medication is used to reverse the effects of opioids. Since Kratom works on the same receptors, you can bet that using kratom with naloxone is a very bad idea. Do not use kratom with naloxone ever!